DIME PROJECT
The resources
Each resource below is grounded in the ASTCT (2019) consensus criteria and was developed through structured input from clinicians, clinical trialists, data scientists, and regulatory and technology stakeholders. Information was gathered through stakeholder interviews and multistakeholder workshops, then refined through external expert review.
Feasibility assessment for outpatient CRS monitoring
A stakeholder-informed look at what it takes to move CRS monitoring into outpatient and community settings, covering the clinical, operational, and economic conditions for adoption.
Read the full report and work through a readiness checklist to see where your program stands today.
CRS adjudication framework for CAR-T & TCE therapies
A shared method for identifying, documenting, and grading a complete CRS event, so data stays comparable across trials and institutions.
The framework includes a decision flowchart and a supporting guide to help sites consistently capture events.
Clinicians & care teams
Our resources provide you with an approach for monitoring CRS in outpatient and community settings, closer to where patients live
- Site Readiness Checklist across six operational domains
- After-hours alert routing models for the “who answers at 2 a.m.” problem
- Emergency department integration into the safety pathway
Clinical researchers & sponsors
Without a shared definition of a CRS event and its severity, data cannot be compared across sites or trials.
Our resources provide:
- A standardized CRS Adjudication Framework for grading CRS events the same way across sites and trials, so the data becomes comparable
- ASTCT grading that captures the full course of an event, and a reporting template
- Considerations for integrating continuous physiologic data as supporting evidence
- A companion Feasibility Report on outpatient monitoring, including clinical, operational, and economic conditions
Building on a foundation of evidence
Where we started
In 2025, DATAcc by DiMe released resources to support the development of trustworthy CRS de-risking products, by defining a mature digital measures set for CRS detection.
What was still needed
Detection alone does not move care out of the hospital. Sites had no shared way to monitor a CRS event, and no clear read on whether outpatient monitoring is operationally feasible across care settings.
How we addressed the gap
DECODE CRS delivers resources built on structured interviews with stakeholders across clinical care, research, industry, and patient advocacy. Multistakeholder workshops then validated the findings to inform the adjudication framework and feasibility report.
